Assessment of Osteoprotegerin As Monitor Diabetic Nephropathy

The prevalence and complications of diabetes are increasing worldwide. in this work, we aimed at estimating osteoprotegerin (opg) as novel factors for controling diabetic nephropathy. the study involved 90 iraqi volunteers with aged range (35-65) years from both genders. the subjects were subdivided into two groups, (45) with diabetic nephropathy (dn) and (45) control recruited, most assays were measured by enzymic colorimetric methods, serum opg levels were estimated by elisa. the results revealed that opg serum levels were higher compared to control group (p < 0.00001). the pearson,s relationship reports opg level had highly positive with fbg and hba1c (r=0.981, p<0.00001), (r=0.350, p=0.020) respectively. in contrast, strong negatively correlated with insulin level (r= -0.363, p=0.014) respectively. moreover, opg level indicate a significant correlation with parameters of renal function include urea, creatinine, acr and egfr (r=0.629, p=0.04), (r= 0.426, p=0.01), (r= 0.074, p=0.002), (r= -0.612, p=0.001), respectively. these summarized results indicates that opg is a great biomarker for predicting the occurrence of diabetic nephropathy.