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anticancer activity of new 3-secondary amine derivatives containing fused rings of the imidazopyridine
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نویسنده
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hattab ahmed ,al-lami naeemah ,wadi jaafar suhail
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2022 - دوره : 4 - شماره : 3 - صفحه:222 -231
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چکیده
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L2 promoted one-pot protocol was suggested previously for the synthesis of 2-aryl-3-(pyridine-2- ylamino)imidazo[1,2-a]pyridine from 2-aminopyridine with different substituted acetophenone for the synthesis of secondary amine derivatives (a1-a6) compounds. after that, the secondary amine derivatives are reacted with propargyl bromide producing propargylamines (b1-b6) compounds. all synthesized compounds were characterized via ft-ir spectroscopy, some of which were characterized by 1h-nmr spectroscopy and ^13c-nmr spectroscopy. two of imidazo(1,2-a) pyridine derivatives were tested for cytotoxic activity against leukaemia cancer using mtt assay.
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کلیدواژه
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one-pot ,sec.amine imidazo(1 ,2-a)pyridine ,propargyl derivatives ,anti-cancer activity
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آدرس
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university of baghdad, college of sciences, department of chemistry, iraq, university of baghdad, college of sciences, department of chemistry, iraq, al-rafidain university, college of pharmacy, department of pharmacology, iraq
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Authors
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