the synthesis, identification, and evaluation of some new antioxidant activities β-lactam from n-carbazole derivatives

This research involved the synthesis of new four- member cyclic derivatives by reacting carbazole with nah in dry dmf at 0 °c to give a sodium salt carbazole suspended in water and react with chloroacetyl chloride to form chloro-n-carbazole acetamide chemically combining compound (1) with hydrazine hydrate yields and its respective hydrazino derivatives (2). condensation reaction of compound 2 with various aromatic aldehydes to give schiff base derivatives (3-8) 2-azetidinones (9-14) and 2- diazetdinone derivatives (14-26) were synthesized by cyclization of schiff base derivatives (3-8) with chloroacetyl chloride, phenyl isocyanate, and phenyl isothiocyanate, respectively. the physical properties and melting points of the prepared compounds were determined. spectral methods [ir, 1h-nmr, and 13c-nmr] were used to identify new compounds. additionally, the activity and antioxidant capacity of the newly synthesized compounds were determined using the dpph scavenging activity method and compared to a standard, ascorbic acid.