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modification and characterization of subs. triazole on creatinine and studying their antioxidant activity
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نویسنده
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sallal zainab amer ,al-tamimi entesar o.
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2022 - دوره : 4 - شماره : 2 - صفحه:152 -159
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چکیده
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In this work, new creatinine derivatives containing (1,2,4-triazole and 5-subs-1,2,4-triazole) ring have been prepared. in the first step, creatinine was reacted with different acid chloride to form 2-subs. amido creatinine 1[a-d]. in the second step, amido creatinine 1[a-d] was reacted with succinoyl chloride to produce imide derivatives 2[a-d]. in the third step, the imide componds prepared were reacted with hydrazine hydrate to give acid hydrazide derivatives 3(a-d). finally, 1,2,4-triazole derivatives 4-7[a-d] were prepared from the reaction between acid hydrazide with different amide compounds by pellizzari reaction. these new synthesized products have been characterized by ft-ir, 1h-nmr for some of them and were studied regarding the effect of preparing derivatives on antioxidant.
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کلیدواژه
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creatinine ,imide ,acid hydrazide ,4-triazole ,antioxidant activity
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آدرس
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university of baghdad, college of science, department of chemistry, iraq, university of baghdad, college of science, department of chemistry, iraq
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پست الکترونیکی
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intesar1118@gmail.com
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Authors
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