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   modification and characterization of subs. triazole on creatinine and studying their antioxidant activity  
   
نویسنده sallal zainab amer ,al-tamimi entesar o.
منبع journal of medicinal and pharmaceutical chemistry research - 2022 - دوره : 4 - شماره : 2 - صفحه:152 -159
چکیده    In this work, new creatinine derivatives containing (1,2,4-triazole and 5-subs-1,2,4-triazole) ring have been prepared. in the first step, creatinine was reacted with different acid chloride to form 2-subs. amido creatinine 1[a-d]. in the second step, amido creatinine 1[a-d] was reacted with succinoyl chloride to produce imide derivatives 2[a-d]. in the third step, the imide componds prepared were reacted with hydrazine hydrate to give acid hydrazide derivatives 3(a-d). finally, 1,2,4-triazole derivatives 4-7[a-d] were prepared from the reaction between acid hydrazide with different amide compounds by pellizzari reaction. these new synthesized products have been characterized by ft-ir, 1h-nmr for some of them and were studied regarding the effect of preparing derivatives on antioxidant.
کلیدواژه creatinine ,imide ,acid hydrazide ,4-triazole ,antioxidant activity
آدرس university of baghdad, college of science, department of chemistry, iraq, university of baghdad, college of science, department of chemistry, iraq
پست الکترونیکی intesar1118@gmail.com
 
     
   
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