Evaluating Spectra, Thermodynamic and Kinetic Parameters of the Complexation Reaction of Organic Compound Or Chelation Therapy Drug With Some Heavy Metal Pollutants

In this paper, we examined the use of chelation therapy for treating metal intoxication in humans. chelation therapy is the use of chelating agents (complexing agents) to detoxify poisonous metals such as nickel, cobalt, and lead by converting them to chemically inert form that can be excreted without further interactions with the body. the uv-vis measurements were carried out in the water as the best media for this work. the electronic spectrum of free chelate in water solution was characterized by a single band for pyridoxine (vitamin b6), with a single band as λ max nm. adding ni (ii) and co (ii) ions to the chelate solution showed an increase in absorbance with vitamin b6 with a little shift in λ max. this change caused the formation of the complexes. the stoichiometry of the formed complexes was investigated by the method of continuous variation, and they were found in a ratio of (1:1). the stability constants were calculated at four temperatures at the range of (298, 303, 308, 313 and 318) ok. thermodynamic parameters like δho, δgo, and δso were determined at five different temperatures. chemical kinetics showed that this effect was subjected to the pseudo-first-order chelation with ni and co ions.