evaluation of the osteoprotegerin and insulin levels in patient’s serum with hypothyroid and hypothyroid with type 2 diabetes mellitus

The aim of this study: to estimate opg levels in serum of patients with thyroid disorder and thyroid disorder + type 2 diabetics and the relationship between them. the study was conducted on 105 subjects and they were divided into three groups with these inclusion criteria: 70 thyroid disorders and thyroid diabetes patients (female) and 35 healthy controls. the age range was 18 –45 years. the parameters which have been measured include:-age, bmi, tt3, tt4, tsh, fbs, insulin hormone, homa-ir and those of the lipid function test. col, tg, hdl, vldl, and ldl. our results support that hypothyroidism is not the main reason for type 2 diabetes mellitus, but the altered lipid profile in hypothyroid patients is the main implicated in incidence of prediabetes, which represents homa-ir resistance and risk for development of type 2 diabetic mellitus. conclusion depending on the results obtained during this study, the increase in osteoprotegrine levels in hypothyroid and hypothyroid + type 2 dm is not related to these diseases. in other words, opg is not legitimately ensnared in hypothyroidism or type 2 diabetic mellitus pathogenesis. moreover, the disorders in lipid profile levels were legitimately ensnared in hypothyroidism which develops.