synthesis of new heterocyclic containing azo group from 2-n-chloro acetamido creatinine and studying their biological activity

The present work include synthesized new 2-amino-4-subs. thiozole(1) from reaction of 2-n-chloro acetamido creatinine with thiourea. compound (1) was treated with sodium nitrate and hydrochloric acid in (0-5ºc) to form diazonium salt (2), then diazonium salt reacted with acetylacetone and hydrazine, phenyl hydrazine and 2,4-dinitrophenyl hydrazine to give pyrazole ring (4-6). on the other hand, diazonium salt was react with pyrrole in the presence of glacial acetic acid to form compound (7) and with different schiff bases to produce compounds (8-9). prepared compounds were measured by ir and melting point and some of them by 1hnmr and their biological activity was studied.