synthesis of new 5-aryl tetrazoline from n-2-hydrazido cyclic imides and study of biological activity

This research focused on the synthesis of some new 5-aryl tetrazoline derivatives on cyclic imides via reaction of n-(2-chloro acetyl) imides with hydrazine hydrate to give compounds (1,2). then, compounds (1,2) reacted with different aromatic aldehydes to give schiff bases compounds (3-10). on the other hand, compound n-(2-chloro acetyl) imides reacted with sodium azide to give compounds (11,12). and finally, react schiff bases compounds (3-10) with compounds 11 and 12 to give the tetrazoline ring. the compounds prepared were characterized by ft-ir and some of them by 1h-nmr. the effects of the preparing compounds on some strains of bacteria and fungi were studied.