anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo [1,2-a] pyrimidine

In this study, new series of 2-aryl-3-(pyrimidine-2-ylamino)imidazo[1,2-a]pyrimidine derivatives (3-secondary amine) were synthesized through one-pot reaction of aromatic ketones and 2-aminopyrimidine. these reactions were performed in the presence of i2 and dmso. derivatives of 3-amine compound were reacted with propargyl bromid to yield 2-phenyl-n-(prop-2-yn-1-yl)-n-(pyrimidine-2-yl) derivatives of imidazo/pyrimidine rings. then, by mannich reaction, one of 3-secondary amine derivatives (contains nh2 group) (1d) was reacted with different aromatic amines to form mannich bases. all synthesized compounds were characterized via ft-ir spectroscopy, some of which were characterized by 1h-nmr spectroscopy. other derivatives of imidazo(1,2-a)pyrimidine(1c,2c,2d,3a) were evaluated for anti-oxidant activity and one of these derivatives (2d) was tested for cytotoxic activity against breast cancer using mtt assay.