kf/cp nps as an efficient nanocatalyst for the synthesis of 1,2,4-triazoles: study of antioxidant and antimicrobial activity

In this research, a green procedure and conventional methodology have been developed for the synthesis of a series of 3mercapto1,2,4triazole derivatives (4af) in the presence of  kf/clinoptilolite nanoparticles (kf/cp nps) as catalyst in water at 80 oc. also, diphenylpicrylhydrazine (dpph) radical trapping and ferric reduction activity potential (frap) assays are used for evaluation of antioxidant activity of some synthesized compounds (4a4d). besides, the antimicrobial activity of some synthesized compounds was studied employing the disk diffusion test on grampositive bacteria and gramnegative bacteria. this procedure has some advantages such as short time of reaction, simple and green procedure, using lowcost catalyst, excellent yield of product and employing different substrate.