nephrotic syndrome associated with carcinoma of unknown primary ‎treated with chemotherapy: a rare case report

Different glomerular diseases are associated with various neoplasms. it seems obvious that ‎carcinoma of unknown primary (cup) induced nephrotic syndrome is rare. in this regard, the ‎present article introduces a patient suffering from nephrotic syndrome associated with cup. ‎patient is a 65yearold nonsmoker male who referred to the clinic for onemonth generalized ‎edema. the patient was also complaining from coughing and bulky yellowish sputum with no ‎signs of blood. patient’s chest radiography revealed pulmonary pleural effusion of the left lung, ‎but no other pathological findings were revealed. patient’s cytology report of pleural fluid ‎indicated metastatic carcinoma, and therefore, the patient needed additional examinations so that ‎the origin of metastases (lung, gastrointestinal tract, pancreas, etc.) could be detected. finally, ‎chemotherapy treatments began when the patient was diagnosed with carcinoma of unknown ‎primary (cup). with the continuation of chemotherapy treatment and followup after more than ‎a year of treatment, the patient is now generally welloff; his nephrotic syndrome has also been in ‎remission parallel to chemotherapy. significant point in the treatment of this patient is ‎proteinuria, hypercholesterolemia and ‎ hyponatremia remission in two stages of chemotherapy. ‎these findings suggest probable paraneoplastic nephrotic syndrome.‎ the treatment of paraneoplastic is the treatment of underlying cause.