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application of [pyridine-1-so3h-2-cooh]cl as an efficient catalyst for the preparation of hexahyroquinolines
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نویسنده
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moosavi-zare ahmad reza ,afshar-hezarkhani hadis
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2020 - دوره : 2 - شماره : 4 - صفحه:465 -474
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چکیده
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Pyridinium-1-sulfonic acid-2-carboxylic acid chloride {[pyridine-1-so3h-2-cooh]cl} was synthesized and applied as a novel and efficient catalyst for the preparation of hexahydroquinolines by the one-pot multi-component condensation reaction of various aryl aldehydes with dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate under mild and solvent-free conditions. low cost, non toxic nature, simple work-up and excellent yields of products are the main advantages of this work.
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کلیدواژه
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pyridinium-1-sulfonic acid-2-carboxylic acid chloride; hexahydroquinoline; multi-component condensation; β-ketoester; solvent-free
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آدرس
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sayyed jamaleddin asadabadi university, department of chemistry, iran, sayyed jamaleddin asadabadi university, department of chemistry, iran
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پست الکترونیکی
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hadisafshar78@yahoo.com
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Authors
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