synthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives

In this paper, we present the convenient syntheses of some new phenyl hydrazin derivatives 8 (a-h). for this purpose, condensation of thiosemicarbazide and acenaphtylene -9,10-quinone was performed to form acenaphtho[1,2-e]-1,2,4- triazine-9(8h)-thiones . afterwards, the subsequent reaction with benzyl chloride derivatives was subjected to hydrazine and, then, the reaction was proceeded with different benzaldehyde derivatives to achieve 9-(phenyl imino hydrazin)- acenaphtho[1,2-e]-1,2,4-triazine derivatives (8a-h) in good yield. the cytotoxicity of the synthesized compounds was also studied against human cancer cell lines including breast (mcf-7), ovarian (skov3) and lung (a549) cell lines. among them 8b, 8c and 8h showed moderate to good activity.