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Synthesis and Molecular Docking of Novel N-((2-Chloroquinolin-3-Yl) Methylene)-4-Methylbenzenamine Derivatives As Anti-Hiv-1 Reverse Transcriptase Inhibitors
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نویسنده
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Fazlinezhad Maassoumeh ,Nakhaei Ahmad ,Eshghi Hossein ,Saadatmandzadeh Mohammad
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منبع
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Eurasian Chemical Communications - 2019 - دوره : 1 - شماره : 2 - صفحه:125 -133
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چکیده
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In this research work, a proficient method has been developed for the preparation of novel n-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine derivatives from 2chloroquinoline3carbaldehyde derivatives and ptoluidine in ethanol as solvent and using catalytic amount of acetic acid under reflux conditions to obtain desired products in good yields. the identification of all the synthesized compounds was confirmed by melting point, ftir, 1h nmr, and 13c nmr. also, in present work all the synthesized compounds were evaluated for their molecular docking as anti-hiv-1 reverse transcriptase inhibitors using gold 5.2. software. the result of molecular docking showed that all the compounds established ‘π–π’ interactions with side chain of amino acid.
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کلیدواژه
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N-((2-Chloroquinolin-3-Yl) Methylene)-4-Methylbenzenamine ,Molecular Docking ,P-Toluidine ,2-Chloroquinoline-3-Carbaldehyde ,Anti-Hiv ,Vilsmeier-Haack Reagent
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آدرس
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Payame Noor University, Department Of Chemistry, Iran, Islamic Azad University, Mashhad Branch, Young Researchers And Elite Club, Iran, Ferdowsi University Of Mashhad, Faculty Of Science, Chemistry Department, Iran, Ferdowsi University Of Mashhad, Faculty Of Science, Chemistry Department, Iran
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Authors
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