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Choline chloride based eutectic solvent: a highly efficient reaction media for the synthesis of 3,4-dihydropyri midin-2(1H)-thiones
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نویسنده
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malamiri fatemeh ,badri rashid ,khaksar samad ,salahshour peyman
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منبع
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journal of composites and compounds - 2022 - دوره : 4 - شماره : 12 - صفحه:153 -157
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چکیده
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A mild and green protocol was developed for three-component, one pot synthesis of 3,4-dihydropyrimidin-2(1h)-thione derivatives in a deep eutectic solvent (des) without the use of a catalyst or any other additive. des based on choline chloride (chcl) and urea offered high reaction yield and was proper for a wide range of aromatic aldehydes. in addition, after 3,4-dihydropyrimidin-2(1h)-thione synthesis, des could be easily recycled and reused five times without any obvious changes in catalytic activity. in general, the procedure offers a number of benefits, including clean reaction profile, avoiding the use of typical toxic catalysts, an easy workup procedure, short reaction times, and low prices.
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کلیدواژه
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Deep Eutectic Solvent ,Green solvent ,Dihydropyrimidine ,MulticomponentBiginelli condensation
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آدرس
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islamic azad university, ahvaz branch, department of chemistry, Iran, islamic azad university, ahvaz branch, department of chemistry, Iran, islamic azad university, ayatollah amoli branch, department of chemistry, Iran. university of georgia, school of science and technology, Georgia, university of georgia, school of science and technology, Georgia
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Authors
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