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Targeted drug delivery by bone cements
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نویسنده
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kheradmand zahra ,rabiei maryam ,noori tahneh akram ,shirali elham ,abedi morteza ,dashtipour bahareh ,barati elham
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منبع
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journal of composites and compounds - 2022 - دوره : 4 - شماره : 10 - صفحه:59 -73
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چکیده
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Bone cement (bc) is one of the most crucial materials for the substitution of damaged bones. polymer or ceramic can be used as cement materials. systemic drug delivery to the bone is difficult since human bone has limited perfusion. bc can carry drugs directly to the bone without causing adverse effects on healthy tissues, so it is a good choice for targeted drug delivery. growth factors in addition to anti-inflammatory, anticancer, analgesic, and antibiotic reagents are just a few of the medicinal chemicals that may be added into bc for various treatment techniques. our goal in this review is to introduce diverse bcs, drug loading mechanisms in bcs, and ultimately their clinical applications in dental potentials, inflammation therapy, bone infection, treatment of osteoporosis, coating of implants, and cancer therapy.
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کلیدواژه
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Targeted delivery ,Bone cement ,Anti-infection ,Coating ,Cancer therapy ,Dental application
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آدرس
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islamic azad university, maragheh branch, department of agriculture, Iran, tehran university of medical sciences, department of obstetric and gynecology, Iran, islamic azad university pharmaceutical science branch, department of pharmaceutical chemistry, Iran, tehran university of medical sciences, school of medicine, yas hospital, Iran, bojnurd university, department of medicine science, Iran, alzahra university, department of chemistry, Iran, shahid beheshti university of medical sciences, school of medicine, Iran
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Authors
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