synthesis and characterization of the novel 80s bioactive glass: bioactivity, biocompatibility, cytotoxicity

In this research, the 80s bioactive glass with different ca/p ratios was prepared by the sol-gel route. scanning electron microscopy (sem), transmission electron microscopy (tem), energy dispersive spectroscopy (eds), x-ray diffraction (xrd), and fourier transforms infrared spectroscopy (ftir) were used to study the apatite structure and shape. according to the results, the 78sio2–17p2o5–5cao bioglass showed a higher rate of crystalline hydroxyapatite (ha) on its surface in comparison with the other bioglasses. after 3 days of immersion in the sbf solution, spherical apatite was formed on the 78sio2–17p2o5–5cao surface, which demonstrated high bioactivity. a statistically significant promotion in proliferation and differentiation of g292 osteoblastic cells was also observed. regarding its optimal cell viability and bioactivity, the 78sio2–17p2o5–5cao bioactive glass could be offered as a promising candidate for bone tissue applications.