topical use of saussurea costus (falc.) lipsch. (qost) oil in pediatric nocturnal enuresis in comparison with sesame oil, a randomized double-blind clinical trial

Nocturnal enuresis is one of the most common chronic problems of childhood. it hasa significant effect on health and quality of life of children and their families. despitepharmacological treatments, enuresis in most children relapses after the medication isdiscontinued. also available drugs have many side effects that limited their uses. so,we compared the effect of topical use of saussurea costus (falc.) lipsch. (qost) oil as apersian medicine product on pediatric nocturnal enuresis in a parallel randomized doubleblinded study. eighty-two patients aged 5 to 15 years who were diagnosed as monosymptomaticnocturnal enuresis were allocated to receive costus oil or sesame oil topicallybelow the navel twice a day for 4 weeks. patients were evaluated prior to and followingend of the study in terms of frequency of enuresis and any observed adverse events. theresults were evaluated with valid plutss questionnaire. for evaluation, chi-square andfisher's exact tests, mann-whitney and wilcoxon tests were used. significant p valuewas < 0.05. a significant decrease in mean scores of the questionnaires was noted in bothgroups. the results before and after the intervention were significantly different in bothgroups, but there was no statistically significant difference between the intervention andcontrol groups. at the end of the 4th week, the frequency and volume of enuresis showeda 46.2 percent reduction in costus oil group and a 25.5 percent reduction in sesame oil tus oil group is 74.5%; while in the sesame oil group is 69%. no drug side effect wasnoticed in this study. based on the results of this study, costus oil is effective in childrenwith monosymptomatic nocturnal enuresis; however, there is no significant differencebetween costus oil and sesame oil.