Study the Relation of Serum Level of IL-33 with Severity of COPD Disease

Background: cytokines are important in many pathobiological processes of chronic obstructive pulmonary disease (copd). this study aimed to determine the relationship between serum levels of interleukin-33 (il- 33) and the severity of copd disease. method: in this cross-sectional research, the study population consisted of all copd patients referring to the pulmonary clinic of imam-ali hospital of zahedan city. sixty patients were selected using the available sampling method. serum il-33 levels were measured by the quantitative elisa method. results: of 60 patients, 23 (38.3%) and 37 (61.7%) subjects were male and female, respectively. analysis shows a significant difference between serum il-33 of the two groups with regard to the severity of copd disease. there was a statistically significant negative relationship between the serum level of il-33 and the severity (decrease of forced expiratory volume in one second (fev1)) of copd disease. conclusion: our results indicate a systemic release of il-33 correlated with the severity of copd.