Evaluating the Impact of Different Genetic Variants on the Prognosis of Patient with COVID-19

Severe acute respiratory syndrome coronavirus 2 (sars-cov-2) emerged in december 2019 in wuhan (china). it soon became widespread so that the world health organization (who) declared the outbreak of covid-19 as a pandemic crisis. this disease has caused significant morbidity and mortality in the world. clinical studies reported that there is a significant correlation between genders, immunogenetic variants, serum levels of some circulating factors, blood groups, and different races with severity and mortality of covid-19 patients. hence, some studies have investigated the role of individual genetic background in the susceptibility and vulnerability to covid-19 infection. it is proposed that host genetic polymorphisms affect the onset and progression of covid-19 infection and could dramatically impact the virus life cycle. this paper aims to review the state-of-the-art research on the roles of genetic variants in host cell membrane proteins and blood circulation factors in the prognosis of patients with covid-19.