Toll-Like Receptor 3 Deficiency in a Child with Recurrent Infections and Diabetes Mellitus

There are more than 400 different primary immune deficiencies worldwide. amongst them,patients with humoral immunodeficiency are more common. most of the innate immune defects,affect the phagocytic system. there are a few cases of toll-like receptor deficiency with innateimmune defects, like tlr3 mutations, which usually present with herpes simplex encephalitis.herein, we report a two-year old boy with tlr3 deficiency, who was presented with recurrentinfections and type one diabetes mellitus.