Vaccination in Patients with Primary Immunodeficiency Disorders

Primary immunodeficiency disorders (pid), are heterogeneous groups of an abnormalityin innate and adoptive immune systems. patients with these disorders, are susceptible to lifethreatening infections. infection control, is an important strategy for improving the qualityof life and prognosis. prophylaxis, intravenous immunoglobulin and antibiotic therapy for along period of time, is an appropriate option for many patients with pid. but vaccination inimmunocompromised patients may play a significant role and various outcomes. dependingon the type of pid, there are different results after the administration of vaccines in patients. insome cases, immune response is perfect and there is a well protection against the syndromes.on the other hand, in some other patients, immune response is impaired, and the vaccination isineffective or even could lead to severe overwhelming side effects. to date, there are no wellestablished guidelines about the vaccination of immunocompromised people. in this review, weare going to describe the latest recommendations for the immunization of patients with pid,based on the published literatures.