three-dimensional zns/mos2 on cellulose paper for determination of digoxin in urine and plasma

The current study describes the in-situ growth of zns/mos2 on cellulose paper using the thin-film microextraction (tfme) method. on cellulose paper, zns/mos2 was grown using a simple, easy, and inexpensive hydrothermal method. the digoxin was quantified after tfme using high-performance liquid chromatography-uv detection (hplc-uv). the effect of effective parameters such as extraction time, extraction temperature, agitation speed, and sample ionic strength was investigated, and the best conditions were selected. under ideal conditions, a calibration curve with good linearity (r2=0.987) and a low limit of detection (lod) in the range of 0.01–100 ng ml-1 was obtained. the detection limits were 0.03 ng ml-1. for the digoxin, the relative standard deviations (rsds) were 5.3%. the method was successfully applied to the study of urine and plasma. relative recoveries were found to range between 96% and102 %. the proposed method provided a straightforward, efficient, and environmentally friendly way for determining digoxin in real-world samples.