3،1-دی‌سولفونیک اسید ایمیدازولیوم کلرید به عنوان کاتالیستی بسیار کارآمد برای سنتز n،n′آلکیلیدن بیس‌آمیدها

در این تحقیق، یک روش جدید بسیار کارآمد برای سنتز n،n′آلکیلیدن بیس‌آمیدها ارائه شده است. واکنش بین آلدهیدهای آروماتیک و آمیدهای نوع اول در حضور مایع یونی اسیدی 3،1-دی‌سولفونیک اسید ایمیدازولیوم کلرید ([dsim]cl) تحت شرایط بدون حلال، این ترکیبات را با بازده بالا در زمان کوتاه داده است.

1,3Disulfonic acid imidazolium chloride as a highly efficient catalyst for the synthesis of N,N′alkylidene bisamides

In this research, a highly efficient new method for the synthesis of N,N′alkylidene bisamides has been introduced. The reaction between aromatic aldehydes and primary amides in the presence of acidic ionic liquid 1,3disulfonic acid imidazolium chloride ([Dsim]Cl) under solventfree conditions afforded these compound in high yields and in short times. Amide functional group is of importance in chemical and medicinal industries. For example, bisamides have been extensively applied in the synthesis of peptide and pseudopeptidecontaining biological materials, and other medicinal compounds. The best method for the preparation of N,N′alkylidene bisamide is the condensation reaction between amide and aldehyde; several catalysts have been reported for this reaction. However, the previous methods for the synthesis of these amide derivatives have drawbacks, as following: high reaction temperature, moderate yields, long reaction times, difficult procedure for catalyst preparation, the use of toxic and volatile organic solvents as reaction media, and no agreement with green chemistry protocols. Thus, introducing new catalysts for this reaction, which have not these drawbacks, is of importance.