novel microwave assisted synthesis of some 3‌־ {2‌־ (1h‌־ 1, 2, 4-triazolyl) ethyl}‌־2‌־ substituted quinazolinone analogues and their evaluation for antimicrobial potential

A significant class of fused heterocyclic compounds, quinazolinones have garnered a lot of interest in medicinal chemistry due to their di-verse range of pharmacological characteristics, which include antimi-crobial, anticancer, anti-inflammatory, anticonvulsant, and antihyper-tensive effects. as a privileged scaffold, the quinazolinone nucleus pro-vides a variety of substitution options at the 2- and 3-positions, fre-quently resulting in compounds with increased bioactivity. many stud-ies have looked into modifying these positions to create new therapeu-tic possibilities, especially in the field of antimicrobial drug discovery. the new sequence to develop 1, 2, 4 ־triazole derivatives via nie-mentowski reactions and heterocyclization using microwave synthesiz-er through benzoxazinone intermediate formation was discussed. 1, 2, 4־ triazole and 3‌־ {2‌־ (1h‌־ 1, 2, 4- triazolyl) ethyl} ־2  ־ substituted quinazo-linone derivatives were derived and investigated by ir spectroscopy, mass spectrometry and nmr techniques. these new triazole analogues have been tested for their in vitro antibacterial and antifungal proper-ties against a variety of gram-positive, gram-negative, and fungal spe-cies. these new analogues show moderate antibacterial and antifungal action by inhibiting growth by 30-40% against s. aureus, e. coli, c. albi-cans, and a. niger.