a comparative study of dissolution profiles on various brands of diclofenac sodium prolonged release tablet formulation

This study aims to analyse and compare the disintegrating patterns of prolonged-release tablets of diclofenac sodium purchased from a variety of brands that are commercially available on the indian national market. each formulation contains the same quantity of the active pharmaceutical ingredient, but the excipients used may be of a different type or in a different proportion than those used in the other formulations. on the dissolution apparatus, using the same dissolution medium with a ph of 7.5, the effect of these formulation variations on the in vitro release qualities of the various dosage forms was compared. during the course of this investigation, it was discovered that branded formulations offered for sale by well-known pharmaceutical companies demonstrate usp-compliant release. on the other hand, formulations manufactured by local firms do not conform to the standards’ requirements.