The Best Time To Prescribe Prophylactic Antibiotics Before Spinal Anesthesia in Foot and Ankle Surgery and Its Effects on Hemodynamic Status During Anesthesia

This study set out to determine the impact of a single dose of antibiotic prophylaxis on the incidence of ssis following foot and ankle surgery, which have the highest infection rate. the study looked at whether or not removing a foot and ankle surgery in the lower leg would result in a lower rate of surgical site infections (ssis) after a single prophylactic antibiotic dose.patients undergoing removal of orthopedic implants to treat fractures below the knee were enrolled in the multicenter, double-blind, randomized wound infections following implant removal trial. the trial was conducted in 17 teaching hospitals and 2 academic hospitals.cefazolin sensitivity was found in 14 microorganisms (74%) while it was absent in 5 (26%) of the microorganisms. no growth was found in the culture swabs taken from 2.7% of patients, and in 45.5% of patients with an ssi diagnosis, no culture swabs were taken. the identified microorganisms were cefazolin sensitive in 87.2% of the cases.one intravenous dose of cefazolin given prior to surgery among patients having foot and ankle surgery did not lower the risk of surgical site infection within 30 days of surgery.