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   influence of arabinofuranosylcytosine-5`-monophosphate and its emoxipin salt on viability and functional status of peripheral blood lymphocytes subpopulations  
   
نویسنده sysa aliaksei ,labai maryna ,kvasyuk eugeni ,ivuts uliana ,khanchevskii maksim
منبع progress in chemical and biochemical research - 2019 - دوره : 2 - شماره : 4 - صفحه:178 -184
چکیده    the influence of the modified nucleotide arabinofuranosylcytosine-5`-monophosphate in the form of the free acid (ara-cmp) and its salts with emoxipin (ara-cmp+em) on the viability of peripheral blood mononuclear cells, the lymphocyte proliferation of mitogen-stimulated cells was studied. it was shown that emoxipin - the compound with strong antioxidant properties - does not lead to inhibition of the main function of the antimetabolite ara-cmp, namely, cell growth arrest (p = 0.96) and lysis of target cells (p = 0.97). under the conditions of nonspecific stimulation of lymphocytes, ara-cmp at high concentrations (10^-4 m) increased in both ifnγ-secreting t-lymphocytes (five times) and ifnγ-secreting other lymphocytes (three times). emoxipin led to almost complete leveling of the detected effect.
کلیدواژه antimetabolites ,ara-cmp ,antioxidants ,emoxipin ,proliferation
آدرس belarusian state university, international sakharov environmental institute (isei), belarus, belarusian state university, international sakharov environmental institute (isei), belarus, belarusian state university, international sakharov environmental institute (isei), belarus, belarusian state university, international sakharov environmental institute (isei), belarus, belarusian state university, international sakharov environmental institute (isei), belarus
پست الکترونیکی maks.khanchevskiy@bk.ru
 
 

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