influence of arabinofuranosylcytosine-5`-monophosphate and its emoxipin salt on viability and functional status of peripheral blood lymphocytes subpopulations

The influence of the modified nucleotide arabinofuranosylcytosine-5`-monophosphate in the form of the free acid (ara-cmp) and its salts with emoxipin (ara-cmp+em) on the viability of peripheral blood mononuclear cells, the lymphocyte proliferation of mitogen-stimulated cells was studied. it was shown that emoxipin - the compound with strong antioxidant properties - does not lead to inhibition of the main function of the antimetabolite ara-cmp, namely, cell growth arrest (p = 0.96) and lysis of target cells (p = 0.97). under the conditions of nonspecific stimulation of lymphocytes, ara-cmp at high concentrations (10^-4 m) increased in both ifnγ-secreting t-lymphocytes (five times) and ifnγ-secreting other lymphocytes (three times). emoxipin led to almost complete leveling of the detected effect.