analytical method: determination of famotidine drug using chemiluminescence method

This study involved the development of a novel, cost-effective, fast, and highly sensitive analytical technique for quantifying minimal amounts of the drug famotidine through chemiluminescence. the method is centred around the measurement of energy emitted as a result of the interaction between the drug and luminol in an alkaline solution; this interaction generates an electronically excited intermediate state, releasing a portion of the system’s energy as photons. the method was sensitive for the analysis of famotidine. the linear calibration curve (lr) is obtained in the range 2-12 mg ml-1, with a high correlation coefficient (r2) of 0.9929. the molecular absorption coefficient  (ε) was calculated at 2621×10^4 l mol-1 cm-1. the method displayed excellent sensitivity with a sandell’s sensitivity of 1.287×10^-5 mg cm-2, the detection limit (lod) was found to be 0.0314 mg ml-1, and the limit of quantification (loq) was 0.0952 mg ml-1. this study found that recovery was obtained at 104 - 96.5 %, and the relative standard deviation (rsd%) was below 1.981%. the results showed that the proposed technique has efficient recovery for measuring famotidine in pharmaceutical preparations.