Magnetic bentonite nanocomposite for removal ofamoxicillin from wastewater samples using response surface methodology before determination by high performance liquid chromatography

In this study, feasibility of magnetic bentonite nanocomposite for removal of amoxicillin from wastewater samples was evaluated by high performance liquid chromatography (hplc). magnetic bentonite synthesized by co-precipitation of bentonite and fe3o4 and used for removal of amoxicillin from water samples. response surface methodology on central composition design (ccd) was applied for designing of experiment and building of model. three factors including ph, adsorbent dose and temperature were studied and used for quadratic equation model to prediction of optimal points. by solving the equation and considering regression coefficient (r2 =0.98). the optimal points of main parameters were obtained as a ph of 4.68, the adsorbent dosage of 1.50 g and the temperature of 48.9˚c. results showed that three factor are significant on removal efficiency and experimental data are in good agreement with predicted data. proposed methods were used to analysis of amoxicillin in three real samples.