Symmetrical N2O2 Tetradentate Schiff Base Complexes: Antibacterial Properties

Three schiff bases, (h2ln), were successfully synthesized by condensing different 3,5-dihalosalicylaldehydes (chloro, bromo, and iodo as haloatoms) with 2,2-dimethyl-1,3-propanediamine. furthermore, their transition metal complexes, (mln), were prepared by refluxing the schiff bases with corresponding metal(ii) acetate in methanol. to thoroughly analyze the synthesized compounds, various spectroscopic techniques, such as: ft-ir and 1h nmr, along with analytical methods like chn analysis were employed. to assess their antibacterial activity in vitro, the compounds were tested against two categories of bacteria: staphylococcus aureus and bacillus cereus representing gram-positive bacteria, and escherichia coli and pseudomonas aeruginosa representing gramnegative bacteria. ampicillin and erythromycin were used as reference antibacterial drugs.