investigation on the relationship between d-dimer and cell blood count indices in covid-19 prognosis: a retrospective study on 320 covid-19 patients

Introduction: due to the spreading of coronavirus infection in 2019 (covid-19) throughout the world, tracking cell blood count (cbc) of moderate to severe covid-19 patients could provide new insights for the prognosis prediction. materials and methods: in this observational-retrospective study, d-dimer and cbc documents of 320 confirmed covid-19 patients hospitalized in shamsoshomus clinic, mashhad, iran, were evaluated. receiver operation characteristics (roc) curve was analysed to determine specificity and sensitivity of d-dimer and hematological indices, including white blood cell (wbcs), lymphocytes, monocytes, eosinophil, red blood cell width (rdw), platelets (plt), and mean of platelet volume (mpv). results: this study included 157 (49.1%) male and 163 (50.3%) female covid-19 patients between 14 to 96 years old. according to their status in the duration of hospitalization, patients were considered in the good outcome group (n=215) and poor outcome group (n=105). a significant difference was observed in d-dimer, wbcs, pmn, lymph, monocytes, eosinophil, and rdw between the two groups (p<0.001). the highest sensitivity and the lowest specificity belonged to rdw (99%, 4%), wbcs (98%, 4%), pmn (99%, 11%) and d-dimer (96%, 42%). d-dimer indicated a significant association with wbcs, pmn, and rdw (p<0.05). conclusion:the present study revealed that wbcs and rdw might be recommended for the covid-19 prognosis prediction due to their high comparable sensitivity to d-dimer.