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Occult Hepatitis B Virus Among the Patients With Abnormal Alanine Transaminase
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نویسنده
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Makvandi Manoochehr ,Neisi Niloofar ,Khalafkhany Davod ,Makvandi Kamyar ,Hajiani Eskandar ,Shayesteh Ali Akbar ,Masjedi Zadeh Abdolrahim ,Sina Amir Hosein ,Hamidifard Mojtaba ,Rasti Mojtaba ,Aryan Ehsan ,Ahmadi Kambiz ,Yad Yad Mohammad Jafar
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منبع
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jundishapur journal of microbiology - 2014 - دوره : 7 - شماره : 8 - صفحه:1 -5
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چکیده
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Background: the occult hepatitis b infection (obi) is defined as the presence of hepatitis b virus (hbv) dna in the sera or in the liver biopsy and the absence of hepatitis b surface antigen (hbsag) by serological test.objectives: the current study aimed to evaluate the occult hbv infection by polymerase chain reaction (pcr) and determine hbv genotyping among the patients with abnormal alanine transaminase (alt) in ahvaz city, iran.patients and methods: the sera of 120 patients, 54 (45%) females and 66 (55%) males, with abnormal alt 40-152 iu were collected. all the patients were negative for hbsag for more than one year. the patients` sera were tested by pcr using primers specified for the s region of hbv. then the positive pcr products were sequenced to determine hbv genotyping and phylogenic tree.results: of these 120 subjects, 12 (10%) patients including 6 (5%) males and 6 (5%) females were found positive for hbv dna by pcr, which indicated the presence of occult hbv infection among these patients. the sequencing results revealed that genotype d was predominant with sub-genotyping d1 among obi patients.conclusions: occult hepatitis b infection is remarkably prevalent in ahvaz, iran, and should be considered as a potential risk factor for the transmission of hepatitis b virus throughout the community by the carriers.
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کلیدواژه
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Occult ,Alanine Transaminase ,Hepatitis B ,Polymerase Chain Reaction
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آدرس
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ahvaz jundishapur university of medical sciences, Infectious and Tropical Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Virology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Virology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Gastroenterology and Hepatology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Gastroenterology and Hepatology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Gastroenterology and Hepatology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, Danesh Laboratory, Pathology Unit, Danesh Laboratory, Tehran, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Virology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Virology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, mashhad university of medical sciences, Antimicrobial Resistance Research Center, Department of Medical Microbiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Department of Statistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, ایران, ahvaz jundishapur university of medical sciences, Department of Education Development Center, Ahvaz Jundishapur of Medical Sciences, Ahvaz, IR Iran, ایران
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Authors
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