Epidemiology of Sporadic Cases of Human Enterovirus 92 in Captivated Primates with Acute Diarrhea

Background: enteroviruses are among the most common viruses, which cause more than one billion infections worldwide. enterovirus 92 (ev92) is a newly identified virus, about which few epidemiological data are available.objectives: the aim of this study was to investigate the echoviruses in captive rhesus macaques (macaca mulatta) with acute diarrheal disease in the southwest of china.materials and methods: stool samples (246) of diarrheal monkeys were collected for detection of ev92 by reverse transcription pcr (rt-pcr) as well as analysis of the epidemiological characterizations.results: sequence analysis indicated that echovirus shared the highest nucleotide identity (85%) with the ev92 strain isolated from the rhesus macaques with gastroenteritis from a us primate center. phylogenetic analysis showed that the ev92 isolated in this study had clustered together with other echoviruses isolated from the primates.conclusions: the results suggested that ev92 as a new echovirus may cause acute diarrhea in m. mulatta.