Frequency of Mupirocin Resistant Staphylococcus aureus Strains Isolated From Nasal Carriers in Hospital Patients in Kermanshah

Background: : staphylococcus aureus is a major nosocomial pathogen world wide. mupirocinplays a crucial role in strategies designed to control outbreaks of s. aureus.objectives: the aim of this study was to determine the frequency of mupirocin resistancein s. aureus strains isolated from nasal carriers among the hospitalized patients atkermanshah hospital, iran.patients and methods: a total of 174 s. aureus isolates (sensitive and resistant to methicillin)were collected from the nasal anterior nares of hospitalized patients. all isolateswere tested for mupirocin susceptibility by a disc diffusion method. the minimum inhibitoryconcentration (mic) was determined by an e-test and they were also analyzedby a pcr for the presence of iles-1 and iles-2 genes.results: utilizing the disc diffusion agar method, e-test and pcr, all of the s. aureusstrains tested were susceptible to mupirocin. in this study, the range of mupirocin micswas determined to be between 0.064 and 4 ?g/ml. there was a significant associationbetween mic observed and multi-drug resistant (mdr) carriage (p value 0.04), and resistanceto oxacillin (p value 0.004).conclusions: this is a report of an initial survey of mupirocin resistance in s. aureus, inkermanshah where the use of mupirocin is still limited. perhaps the sensitivity of allisolates to mupirocin in this study is due to the less common usage of this antibiotic,especially in the form of nasal and site sample collections.