Antifungal susceptibility of Candida species isolated from candidura

Candiduria is one of the most common symptoms of urinary tract infectionscaused by several species of candida spp.. several antifungals are available to treatsuch candidal infections. during the last decades, resistance to antifungal especially tonon-albicans species has increased.objectives: the present study aimed to evaluate the susceptibility to antifungal drugs ofcandida species isolated from candiduria in ahvaz.materials and methods: ninety three species of yeasts and yeast like organisms isolatedfrom urine samples [candida albicans (58), c. glabrata (25), c. tropicalis (4), c. krusei(1), unknown candida species (4) and geotrichum species (1)] were used for susceptibilitytests. all species were re-identified based on standard mycological methods. then asuspension of each isolate of overnight cultures was prepared in 1ml of sterile pbs andadjusted to 0.5 mcfarland turbidity standards. in the present study several antifungaldrugs (fluconazole, amphotericine b, ketoconazole, econazole, itraconazole) were usedfor susceptibility test using disk diffusion method.results: in the present study all tested isolates were sensitive/dose dependent to amphotericineb and nystatin, whereas only one isolate of c. glabrata was resistant to both antifungals.resistance against fluconazole (48.4%) and ketoconazole (26.9%) were observedamong tested isolates. resistance against fluconazole was detected among all tested organisms,34.4% of c. albicans, and 7.5% of c. glabrata. on the other hand, all isolates weresensitive to econazole (93.5% sensitive, 6.5% dose dependent).conclusions: it was concluded that candida species isolated from candiduria in hospitalizedpatients had excellent in vitro sensitivity against econazole. other suitable antifungaldrugs were amphotericine b and nystatin, itraconazole. whereas, resistanceagainst ketoconazole (26.9%) and especially fluconazole (48.4%) was significant.