risk factors and outcomes of patients with pseudomonas aeruginosa bloodstream infection in the intensive care unit

Background: bloodstream infections (bsis) caused by pseudomonas aeruginosa have high mortality rates and pose a significant threat to healthcare settings. objectives: we aimed to investigate the clinical risk factors related to mortality and the development of p. aeruginosa with difficult-to-treat resistance (dtr-pa) bsi in the intensive care unit. methods: this was a retrospective, single-center study that included patients with p. aeruginosa bsi who were hospitalized between 2020 and 2022. the risk factors affecting 30-day mortality and the development of dtr-pa were investigated using both univariate and multivariate analyses. results: a total of 140 patients were analyzed. the mean age was (66 ± 17.5) years, and 48% of the patients were male. previous meropenem use was an independent risk factor for dtr-pa bsi (odds ratio, 2.68; 95% ci, 1.24 to 5.80; p = 0.012). multivariate analysis demonstrated that the requirement for inotropic support was an independent risk factor for 30-day mortality [hazard ratio, 2.50; 95% confidence interval (ci), 1.33 to 4.68; p = 0.004]. conclusions: prior meropenem use was an independent risk factor for dtr-pa development. strict policies for carbapenem use and infection control procedures are essential to combat infections caused by dtr-pa.