Combination Therapy with Ceftazidime-Avibactam and Amikacin for Multidrug-Resistant Pseudomonas aeruginosa Infection with Fulminant Myocarditis in a Younger Patient: A Case Report andLiterature Review

Introduction: fulminantmyocarditis is a life-threatening disease among young patients. pseudomonas aeruginosa is distributed in nature and is often spread as an opportunistic pathogen to cause hospital-acquired infections in patients with underlying diseases and low immunity. case presentation: this report presented a case of a 28-year-old woman with fulminant myocarditis followed by p. aeruginosa infection. after hospitalization, she received veno-arterial extracorporeal membrane oxygenation (ecmo) and continuous renal replacement treatment (crrt). initially, piperacillin sodium tazobactam combined with amikacin was used for anti-infection therapy, which had a poor clinical effect. subsequently, it was recommended to use ceftazidime-avibactam and amikacin for treatment. finally, the infection index of the patient returned to normal. conclusions: it is necessary to select correct and effective drugs according to etiology, considering the influence of ecmo and crrt on the patient’s antimicrobial pharmacokinetics/pharmacodynamics (pk/pd). this case could provide a reference for safe and rational drug use in clinical practice.