impact of covid-19 in chronic viral hepatitis b patients on virological, clinical, and paraclinical aspects

Background: coronavirus disease 2019 (covid-19) is caused by an infection in the respiratory tract leading to extrapulmonary manifestations, including dysregulation of the immune system and hepatic injury. objectives: given the high prevalence of viral hepatitis and a few studies carried out on severe acute respiratory syndrome coronavirus 2 and hepatitis b virus (hbv), this study investigated the impact of covid-19 on chronic hepatitis b (chb) patients in the northeast region of iran. methods: in this cross-sectional study, the blood samples were collected from 93 chb patients registered in the patient detection data bank of golestan university of medical sciences, gorgan, iran, and 62 healthy individuals as controls. reverse transcriptionpolymerase chain reaction was adopted to detect covid-19 infection in all the participants’ nasopharyngeal samples. all the participants were subjected to anti-hepatitis c virus, anti-hepatitis delta virus, and liver function tests. then, hbv deoxyribonucleic acid load was detected in chb patients. the collected data were analyzed by statistical tests using spss software (version 20). a p-value less than 0.05 was considered statistically significant. results: in this study, 14% (13/93) and 32.25% (20/62) of chb patients and control individuals were infected with covid-19, respectively. themeanage of chbpatients was 39.6919.58 years, and 71% of them were female. the risk of developing covid-19 in healthy controls was observed to be 2.3 times higher than in patients with chb (0.95% confidence interval: 1.242 - 4.290). on the other hand, the mean values of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in chb patients superinfected with covid-19 were higher than other participants. out of 35.4% of patients with viral hepatitis b that were taking antiviral drugs, only 5.4% had covid-19. conclusions: although chb infection did not predispose covid-19 patients to more severe outcomes, the data of this study suggest that antiviral agents also decreased susceptibility to covid-19 infection. alternatively, careful assessment of hepatic manifestations and chronic viral hepatitis infections in covid-19 patients can lead to more favorable health outcomes.