evaluation of anti-sars-cov-2 igg antibody in healthcare professionals infected with covid-19

Background: the knowledge of antibody’s significance and frequency in patients cured of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is extremely limited. objectives: this study aimed to evaluate anti-sars-cov-2 igg antibodies in patients exposed to sars-cov-2. methods: healthcare professionals infected with sars-cov-2 were enrolled in this study. the levels of anti-sars-cov-2 igg antibodies were detected 15 days after the onset of symptoms and five months later. results: a total of 167 patients with coronavirus disease 2019 (covid-19) were evaluated, including 119 (71.3%) females and 48 (28.7%) males. of the 88 polymerase chain reaction (pcr)-positive patients, 55 (62.5%) had igg-positive antibodies, and of the 79 reverse transcriptase (rt)-pcr-negative patients, 12 (16.9%) had igg-positive antibodies. out of 23 anosmia cases, 19 (82.6%) had positive antibodies. there was a significant relationship between anosmia and positive antibody (p = 0.001), but there was no correlation between antibody titers and gender and other disease symptoms. immortally, 63 (94%) cases demonstrated high levels of anti-sarscov- 2 igg antibodies after five months of infection. moreover, 6.5% (n = 11) of the total population were re-infected with covid-19 six months later. conclusions: overall, anti-sars-cov-2 igg antibodies detectionmaybe an appropriate method to identify suspected patients with a negative rt-pcr test. antibodies can remain high in most infected patients for up to five months after infection. moreover, anosmia seems to be a valuable diagnostic factor, and the healthcare system should implement isolation measures for patients with anosmia.