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   in vitro antifungal activity of luliconazole, efinaconazole, and nine comparators against aspergillus and candida strains isolated from otomycosis  
   
نویسنده shokoohi gholamreza ,rouhi sefidmazgi reza ,etehadnezhad mohammad ,ahmadi bahram ,javidnia javad ,nouripour-sisakht sadegh ,hooshmand farhang ,rezaei-matehkolaei ali ,tabatabaeifar nadia ,ansari saham
منبع jundishapur journal of microbiology - 2021 - دوره : 14 - شماره : 4 - صفحه:1 -8
چکیده    Background: aspergillus and candida species are the most commonly identified fungal pathogens in otomycosis. however, we usually encounter some difficulties in its treatment because many patients show resistance to antifungal agents and present a high recurrence rate. objectives: the current research was conducted to compare the in vitro activities of luliconazole (lul), and efinaconazole (efn) and the nine comparators on aspergillus and candida strains isolated from otomycosis. methods: the in vitro activities of nine common antifungal drugs (amphotericin b (amb), voriconazole (vrc), fluconazole (flu), itraconazole (itc), ketoconazole (kto), clotrimazole (clo), nystatin (nys), terbinafine (trb), and caspofungin (cas)) and two novel new azoles (lul and efn) against 108 clinical isolates of aspergillus and candida species obtained from otomycosis were assessed according to the clsi broth microdilution document. results: the lul and efn had the geometric mean minimum inhibitory concentrations (gm mics) of 0.098 and 0.109 μg/ml against all aspergillus strains, respectively. furthermore, the gm mics of all candida isolates for lul, efn, cas, clo, vrc, amb, itc, kto, flu, nys, and trb were calculated to be 0.133, 0.144, 0.194, 0.219, 0.475, 0.537, 0.655, 1.277, 4.905, 9.372, and 13.592 μg/ml, respectively. additionally, 6 (35.29%), 2 (11.7%), and 1 (5.88%) candida isolates were resistant to flu, cas, and vrc, respectively. conclusions: as the findings indicated, lul and efn showed the lowest gm mic values against the examined species. accordingly, these novel imidazole and triazole antifungal agents can be regarded as proper candidates for the treatment of otomycosis caused by aspergillus and candida strains
کلیدواژه otomycosis ,antifungal susceptibility ,efinaconazole ,luliconazole
آدرس jahrom university of medical sciences, school of medicine, zoonosis research center, department of medical parasitology and mycology, iran, jahrom university of medical sciences, zoonosis research center, department of medical otorhinolaryngology, iran, jahrom university of medical sciences, school of medicine, zoonosis research center, department of medical parasitology and mycology, iran, bushehr university of medical sciences, faculty of paramedical, department of medical laboratory sciences, iran, mazandaran university of medical sciences, school of medicine, student research committee, department of medical mycology, iran, yasuj university of medical sciences, medicinal plants research center, iran, jahrom university of medical sciences, school of medicine, zoonosis research center, department of pathology, iran, ahvaz jundishapur university of medical sciences, infectious and tropical diseases research center, health research institute, iran, tehran university of medical sciences, sina hospital, department of internal medicine, iran, shahid beheshti university of medical sciences, school of medicine, department of parasitology and mycology, iran
پست الکترونیکی samansari1988@yahoo.com
 
     
   
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