the use of moxisaxin for treatment of a decompensated cirrhosis patient with severe pulmonary infection

Introduction: moxifloxacin is recommended for empirical antibiotic treatment of patients with cirrhosis. however, due to a lack of clinical safety data on moxifloxacin in child-pugh c patients, it is unknown how to use moxifloxacin in clinical practice. case presentation: a 76-year-old female with decompensated cirrhosis developed pneumonia during hospitalization. she had an initial failure to respond to imipenem/cilastatin + linezolid therapy. after three-day therapy with imipenem/cilastatin + moxisaxin, her infection symptoms rapidly improved. at this time, she presented a poor response with suspected hepatic encephalopathy. given the worsening clinical symptoms caused by drug hepatotoxicity, moxisaxin was discontinued. then, her body temperature rapidly raised. conclusions: moxisaxin may be a potentially useful antibiotic for hospital-acquired pneumonia in patients with decompensated cirrhosis, but further studies are needed to validate its hepatotoxicity.