tumor necrosis factor-related apoptosis-inducing ligand gene polymorphisms and hepatitis b virus infection

Background: tumor necrosis factor-related apoptosis-inducing ligand (trail) is an apoptotic molecule with a key role in the apoptosis of tumors and virus-infected cells. the association of 1525g/a and 1595c/t polymorphisms in the region of 3’ utr on the trail gene has been shown in many cancers and diseases. polymorphism at the positions of 1525g/a and 1595c/t might influence the clearance of hepatitis b virus (hbv).objectives: this study was carried out to determine the role of the trail gene polymorphisms in clinical outcome of hbv infection.patients and methods: polymerase chain reaction-based restriction fragment length polymorphism (pcr–rflp) was applied to genotype trail polymorphisms at positions 1525g/a and 1595c/t. to evaluate the trail gene polymorphism in the 3’ utr region at position 1525g/a and 1595c/t, 147 patients with hbv infection were divided into three different groups of chronic hepatitis (n = 52), cirrhosis (n = 33), and carrier (n = 62) and there was a group of 101 healthy controls.results: our data showed that genotypes 1525g/a and 1595c/t were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. no significant differences in frequencies of genotype and alleles at positions 1525g/a and 1595c/t were observed between all the three groups (p value > 0.05).conclusions: according to our result, 1525g/a and 1595c/t were in strong linkage disequilibrium and the polymorphisms of the trail gene in the 3’ utr region were not associated with the outcome of hbv infection.