nosocomial yeast infections among cancer patients in egypt: species distribution and antifungal susceptibility profile

Background:the frequency of nosocomial yeast infections has increased dramatically in the recent years. they are considered an important cause of morbidity and mortality in immunocompromised cancer patients. the majority of yeast infections are caused by candida species. however, species like trichosporon and rhodotorula should be considered as possible infectious agents as well. objectives:this study aimed at determining the prevalence of yeast species, their distribution among patients and the antifungal susceptibility profile at oncology center, mansoura, egypt. methods:from december 2016 till november 2017, cancer patients who developed infective episodes two days or more following hospital admission were included in the study. clinical samples were collected according to the site of infection using standard sterile procedures. blood samples were cultured using the bactalert system. fungal identification and susceptibility testing were performed by vitek 2 system. results:eightyseven fungal strains were obtained from our patients. a higher isolation rate was observed in urine samples (47.1%) followed by oropharyngeal (24.1%) and blood (21.8%) samples. the majority of the yeast species were candida albicans (40.2%), c. tropicalis (14.9%), c. parapsilosis (9.2%), c. famata (6.9%) and c. guilliermondii (6.9%). out of the 87 samples, 8 (9.2%) were resistant to fluconazole, 7 (8.0%) were resistant to flucytosine, 5 (5.7%) were resistant to voriconazole and amphotericin b, and no sample was resistant to caspofungin or micafungin. conclusions:vitek 2 system offers a novel method for the early identification and susceptibility testing of different yeast species. it helps to minimize the risk for emergence of resistant species and reduce mortality rates, particularly in cancer patients.