triple therapy with doxorubicin, imatinib and tamoxifen in recurrence desmoids tumor associated with pregnancy: case report and literature review

Introduction: desmoid tumors, also known as aggressive fibromatosis, grow slowly but are locally aggressive. the therapy strategy consists of surgery, and radiation. systemic therapy with non-steroidal anti-inflammatory drugs, antiestrogen compounds, cytotoxic chemotherapy and protein kinase inhibitors are recommended for recurrence, unresectable, advanced disease and failure to response to primary treatment. case presentation: we report on a 35-year-old female patient with advanced fibromatosis of the soft tissue of neck who has been treated with triple therapy including 8 cycles of doxorubicin, tamoxifen daily, and imatinib daily. tumor response was evaluated clinically and by enhanced ct scan imaging. conclusions: 90% reduction in tumor size occurred after 6 months of treatment. the response continued and after 8 courses of doxorobicine treatment switched to triple therapy with imatinib , tamoifen and celexocib