association between vdr gene polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and susceptibility to breast cancer in a sample of southeastern iranian population

Background: vitamin d receptor (vdr) is a key nuclear receptor that is associated with the risk and progression of breast cancer (bc). objectives: the present study investigated the fok1, bsm1, taq1 and cdx2 polymorphisms in the vdr gene and susceptibility to bc in a sample of southeastern iranian population. methods: this case-control study was conducted on 180 women with bc and 178 age-matched healthy women. rflp-pcr method was used for analysis of bsm1 (rs 1544410), apa1 (rs 7975232), fok1 (rs 2228570) and taq1 (rs 731236) and also tetra-arms method for cdx2 (rs 11568820). results: no significant correlation was found between polymorphisms of taq1, fok1 and apa1 with bc, but was for bsm1 (odds ratio (or) = 3.452, 95% ci 1.769 - 6.738; p < 0.001). also, there was a significant correlation between the case and control groups for cdx2 (or = 3.720, 95% ci 2.224 - 6.225; p < 0.001) and allele a in cdx2 had just significant correlation with bc. conclusions: the present study findings showed that there were significant correlations between bsm1 and cdx2 polymorphisms with bc in women of sistan and baluchestan province (southeastern iran). also, signals of rs1544410-bsm1 and rs11568820-cdx2 positions were difference with routes of estrogen and progesterone per person and they probably act independently.