association of toll-like receptors and highmobility group proteins with micrornas in melanoma

Context: micrornas (mirnas) have recently been found to be important targets for cancer therapy in innate immunity. such molecules are highly expressed in a wide variety of tumor cells and play an important role in immune responses, such as apoptosis. evidence acquisition:we searched pubmed, medline, scopus and google scholar databases for the studies published from january, 1998 to october, 2017 with the following keywords: “tlrs”, “microrna”, “cancer”, “hmgb1”, and “melanoma” results: mirnas are mainly classified into 2 different groups, tumor suppressors and oncogenes. mirnas are closely related to damage-associated molecular patterns and pathogen-associated molecular patterns through the innate immunity signaling pathways, such as toll-like receptors (tlrs). this review was carried out to find the relation between melanoma mirnas with innate immune signaling pathways, such as toll-like receptors and high-mobility group box 1. high-mobility groups (hmg) are danger signal molecules, which can involve damage-associated molecular patterns and manage micrornas. conclusions: the important point in this field is that mirna targeted in the immune defense can regulate inflammatory cytokines and alter cancerous phenotypes.