elevated serum 8-hydroxy-2'-deoxyguanosine, nitrite, and nitrate in patients with stage i multiple myeloma

Background: reactive oxygen species are highly active intermediates, which lead to cellular damage during imbalance between oxidative stress/antioxidant towards oxidative stress. free radicals have been proposed to have a crucial role in development and progression of human cancer. objectives: the main aim of this study was to assess the changes in 8-hydroxy-deoxyguanosine (8-ohdg), nitrite (no2-), and nitrate (no3-) levels in patients with stage i multiple myeloma (mm). methods: the serum samples were obtained from 34 patientswith stage imm(22 males and 12 females at stage i)whowere matched with healthy control group. total serum of no2- and no3- levels, in addition to serum 8-ohdg levels, were assayed by using the commercial assay kit. results: compared with the healthy case group, the levels of serum no2- and no3- (2.540.49 vs. 1.750.52mol/l, p < 0.001 and 6.370.94 vs. 2.631.06 mol/l, respectively, p < 0.001) were significantly increased in patients with mm. higher levels of 8-ohdg in mm patients (157.08  13.61 pg/ml) were observed and compared to the control group (61.48  9.93 pg/ml) and indicated that 8-ohdg levels in patients with cancer were significantly increased than those of the control group (p < 0.001). conclusions: significantly increase in oxidative dna damage and end-products of nitric oxide (no) metabolism levels in patients with stage i mm suggest the possible involvement of oxidative stress in mm disease. these alterations can be associated with the imbalance in oxidant-antioxidant status in these patients and may contribute to carcinogenesis of mmby oxidative dna damage.