Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study

Gastric cancer is one of the most common malignant tumors in iran.hypomethylation and/or hypermethylation of dna have been described in gastriccancer and is presumed to be an early event in this process.objective: we hypothesized that single nucleotide polymorphisms of dnmt1 genemay be associated with the genetic susceptibility to gastric cancer.methods: 200 patients and 200 controls, both with iranian origin were studied.three polymorphisms were genotyped by pcr-rflp. allele frequencies andgenotypes were compared between the cases and controls. odds ratios werecalculated and the interaction between polymorphisms, age and sex wereexamined.results: there was no significant association between dnmt1 polymorphisms andgastric cancer.conclusion: we could not show any association between dnmt1 polymorphismsand gastric cancer. larger sets of polymorphisms and sample sizes are required totest the possibility of association between polymorphisms of this gene and gastriccancer.