Her2/neu expression in Wilms' tumor and correlation with histopathologic findings

Background: wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. methods: in the current study, we analyzed her2/neu expression in 40 wilms' tumors. the clinico-demographic data of 40 patients with wilms' tumor were retrieved. immunohistochemical staining for her2/neu was performed. her2/neuimmunoreactivity was evaluated by canadian consensus 2007 scoring system. results: among the 38 specimens with epithelial component, 68.5% were positive for her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. the her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components. conclusion: this study suggested that her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. no significant relationship was found between her2/neu positivity and tumor size and patient's age and gender.